Misoprostol HPMC 1% Dispersion powder
(UK PIRAMAL - exclusive agent in India)
What is Misoprostol?
is a prescription drug used widely to prevent as well as treat non-steroidal anti-inflammatory drug (NSAID)-induced stomach ulcers, for early abortion, to treat missed miscarriages and to induce labor.
As a prescription drug, Misoprostol finds favor among healthcare professionals since it is cheap, stable, and easy to transport as well as administer and unlike many medications, need not be stored under refrigeration.

Chemically speaking, Misoprostol is a synthetic Prostaglandin E1 (Prostaglandins are naturally occurring fatty acids generated by body tissues) analogue, which is responsible for causing myometrial contractions. This medication reduces the amount of acid released by the stomach and thereby protects the stomach lining and minimizes the risk of stomach ulcers.

What are the main uses of Misoprostol?
   • Misoprostol is used to prevent as well as treat stomach ulcers when you are put on NSAIDS like aspirin, ibuprofen, naproxen etc. and you have a propensity to develop ulcers or have a medical history that indicates so.
   • Yet another common use of Misoprostol is in the induction of labor, by causing uterine contractions and cervical ripening. In fact, it has proven to be far more effective than any other medication used for inducing labor, besides being economical as well.
   • Misoprostol also find use as an abortifacient (i.e., a medication that induces abortion) - it is more economical than surgical procedures and less complicated as well.
   • Misoprostol is also used in prevention and treatment of post-partum hemorrhage.

How to use Misoprostol?
This medication should be taken orally, together with food, four times a day. The final dose of the day should always be administered before retiring for the night. You should also avoid taking any antacids containing magnesium within an hour before or two hours after taking Misoprostol. Women should not take their first dose until after the second or third day of their period to rule out or confirm pregnancy.

What are the side effects of Misoprostol?
   • Diarrhea is one of the most common side effects reported after using Misoprostol – under clinical trails, almost 13% of patients complained of dose-related diarrhea.
   • Other common side effects include abdominal pain, nausea, flatulence, headache, dyspepsia, vomiting, and constipation.
   • In most cases, these side effects can be countered effectively with oral analgesics.

What is the recommended dosage of Misoprostol?
Be it any drug, prescribing and administering the right dosage is essential for the successful prevention and treatment of the disease or ailment being addressed. In the case of Misoprostol, the correct dosage depends on gestation, indication, and methods of administration.
Who should not use Misoprostol?
Women who are allergic to prostaglandins should avoid using this medication. In addition, women who are using intrauterine devices (IUD) should remove the same before using Misoprostol.

What should you do if you miss a dose of Misoprostol?
Should you happen to miss a dose of Misoprostol, you should take it as soon as possible. In addition, in case your next dose is due soon, you can skip the missed dose and revert to your regular dosage schedule. Avoid double dosing at all costs.

What precautions should I follow before taking Misoprostol?
   • Do not take Misoprostol if you pregnant as it can cause abortion, premature birth or other defects.
   • It is advisable to use a dependable birth control method if you are using this medication.
   • Do not share this medication with others.
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