Teicoplanin
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What is Teicoplanin? 
Teicoplanin is a bactericidal, glycopeptide antibiotic, produced by fermentation of Actinoplanes teichomyceticus. It is active against both aerobic and anaerobic Gram-positive bacteria.  

How does Teicoplanin work?
Teicoplanin belongs to a group of antibiotics called glycopeptides. Bacteria have an external cell wall that is reinforced by molecules called peptidoglycans. The cell wall is vital for protection against the normal environment of the body in which the bacteria live. 
Teicoplnin works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and these results in the death of the bacteria.
 
 
Teicoplanin and Vancomycin
Teicoplanin has a longer duration of action allowing once daily administration (Vancomycin requires twice daily administration). Teicoplanin, unlike Vancomycin, can be given intramuscularly

What is Teicoplanin used for? 
Teicoplanin is used to treat serious infections of the heart and blood. It is not absorbed from the gut and is therefore only given by injection or infusion.
Teicoplanin is mainly used in moderate to severe infections with Gram-positive organisms.
Inflammation of the lining of the heart cavity and heart valves due to infection (endocarditis)
Prevention of severe infection (usually after surgery)
Treatment of serious staphylococcal bacterial infections

Teicoplanin is extremely useful in the following clinical situations:
Severe lower respiratory tract infections with presumed or documented Gram-positive infection 
Skin and/or soft-tissue infection
Infection where "methicillin-resistant Staphylococcus aureus" (MRSA) is documented or suspected

Microorganisms usually or frequently sensitive to teicoplanin: 
Staphylococcus aureus
Staphylococcus epidermidis
Streptococci 
 
 
Teicoplanin Resistance: 
There are a small number of organisms that are inherently resistant to teicoplanin. These are usually not pathogenic, or not often encountered, but include Erysipelothrix, Leuconostoc, Pediococcus, and some Lactobacilli. 

Teicoplanin Warning:
People taking this medicine should have regular blood tests to monitor their kidney and liver function. It is recommended that regular blood tests be performed to check levels of the blood components.

Teicoplanin's effect on Pregnancy and Breastfeeding:
Teicoplanin should be used with caution during pregnancy, and only if the expected benefit to the mother is greater than any possible risk to the foetus. Seek medical advice from your doctor.  Teicoplanin should be used with caution by breastfeeding mothers, and only if the expected benefit to the mother is greater than any possible risk to the baby. Seek medical advice from your doctor.

Teicoplanin Side Effects: Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect. 
 
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